Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00051-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590921000515%3Fshowall%3Dtrue

 Single-cell transcriptome and whole-genome sequencing of HSPCs from individuals with MPNs

This paper use scRNA to detect somatic mutations. It showed tumor mutaiton occured dacades ago. The tumor cells have a selective growth advantage.