Sohee Kim and Chuna Kim
http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.2239
Recently, the Tabula Muris Senis (Mouse Aging Cell Atlas), which analyzes the aging in mice with scRNA-seq, has been released (Almanzar et al., 2020) (Table 3). In this study, 23 organs from 19 male and 11 female mice have been analyzed at 6 time points. The study observed the appearance of aging-specific cell types in various tissues, such as the liver and bladder, and the immune infiltration of various tissues. In addition, the number of T and B cells in gonadal adipose tissues increased with age, and the B cell cluster highly expressing immunoglobulin J was found specifically in old mice. Therefore, scRNA-seq enables the monitoring of the changes in cell population and the discovery of new rare populations associated with aging.
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