cyclin C and mitochondria

 ROS-induced degradation of Med13 by SCF^Grr1 mediates mitochondrial fragmentation and cell death.

D. Stieg  ; ... K. Cooper 

cyclin c --> mitochondria fission

ROS stress --> MAPK

No stress: cyclin C in nuclear
Stress translocate cyclin C to cytosal.

http://www.ncbi.nlm.nih.gov/pubmed/25609094

So, cyclinC may influence yeast lifespan through its influence on mitochondria? 

cyclin C and mitochondria

 ROS-induced degradation of Med13 by SCF^Grr1 mediates mitochondrial fragmentation and cell death.

D. Stieg  ; ... K. Cooper 

cyclin c --> mitochondria fission

ROS stress --> MAPK

No stress: cyclin C in nuclear
Stress translocate cyclin C to cytosal.

toread,

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

• Claire E. Schaar ¶,
  
  
• Dylan J. Dues ¶,
  
  
• Katie K. Spielbauer ¶,
  
  
• Emily Machiela,
• Jason F. Cooper,
• Megan Senchuk,
• Siegfried Hekimi,
• Jeremy M. Van Raamsdonk mail

 

http://www.plosgenetics.org/article/Authors/info:doi/10.1371/journal.pgen.1004972

 

DHR stain, YP2%D, YP0.5%D, BY4743, RM112N, M2-8

DHR time course, RM112N, M2-8, YPS163, SGU57