Maisonneuve09 stated that "Carbonyl derivatives are mainly formed by direct metal-catalysed oxidation (MCO) attacks on the amino-acid side chains of proline, arginine, lysine and threonine residues. " Maisonneuve09 then focus on the RKPT-enriched regions in proteins.
More genomics methods have been applied to identify carbonylation sites.
Connection to ROS damage and aging? Do aging-hub aging tend to avoid carbonylation motif??
References
- Maisonneuve, E, et al, 2009 Plos ONE, Rules Governing Selective Protein Carbonylation
- AG Madian, FE Regnier - Journal of proteome research, 2010, Proteomic identication of carbonylated proteins and their oxidation sites.
- RC Bollineni, R Hoffmann, M Fedorova - Journal of proteomics, 2011, Identification of protein carbonylation sites by two-dimensional liquid chromatography in combination with MALDI-and ESI-MS.
- Nystrom, Thomas, 2005, Nature, Role of oxidative carbonylation in protein quality control and senescnece.
