Showing posts with label genetic capacitor. Show all posts
Showing posts with label genetic capacitor. Show all posts
Monday, July 7, 2014
Zhao et al Cell, 2005, navigating chaperone network, hsp90
Hsp90 regulates 10% of the yeast genome, 627 putative hsp90 substrates.
Zhao05Cell used geldanamycin screen 4 times, and found 200 ORFs dependent on Hsp90 for, provided in table S4.
Notable missing 'known(?)' substrates: Ste11, Hap1, Ctf13/Skp1, Rpn components of proteasome.
49 ORF genetically interacts with Hsp90 by SGA and GS.
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