aging methylation data, single cell, Transcription factor

Inference of age-associated transcription factor regulatory activity changes in single cells

https://www.nature.com/articles/s43587-022-00233-9#data-availability

 

re we present and validate a TF activity estimation method for single cells from the hematopoietic system that is based on TF regulons, and apply it to a mouse single-cell RNA-sequencing atlas, to infer age-associated differentiation activity changes in the immune cells of different organs

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE56046

Series GSE56046 Query DataSets for GSE56046
Status	Public on Nov 24, 2014
Title	Transcriptomics and methylomics of human monocytes [methylome]
Organism	Homo sapiens
Experiment type	Methylation profiling by genome tiling array
Summary	The MESA Epigenomics and Transcriptomics Study has been launched to investigate potential gene expression regulatory methylation sites in humans by examining the association between CpG methylation and gene expression in purified human monocytes from a large study population (community-dwelling participants in the Multi-Ethnic Study of Atherosclerosis (MESA)). The MESA Epigenomics and Transcriptomics Study was funded by a National Heart, Lung and Blood Institute grant (R01HL101250) through the NIH Roadmap Epigenomics Program in 2009.