youth’ protein may drive aging in the eye

 

NIH study finds loss of ‘youth’ protein may drive aging in the eye

Loss of the protein pigment epithelium-derived factor (PEDF), which protects retinal support cells, may drive age-related changes in the retina, according to a new study in mice from the National Eye Institute (NEI). The retina is the light-sensitive tissue at the back of the eye, and aging-associated diseases of the retina, like age-related macular degeneration (AMD), can lead to blindness. This new finding could lead to therapies to prevent AMD and other aging conditions of the retina. The study was published in the International Journal of Molecular Sciences. NEI is part of the National Institutes of Health.

Reference:

https://www.nih.gov/news-events/news-releases/nih-study-finds-loss-youth-protein-may-drive-aging-eye

Rebustini IT, Crawford SE, Becerra SP. “PEDF deletion induces senescence and defects in phagocytosis in the RPE.” July 13 2022. Int J Mol Sci. https://doi.org/10.3390/ijms23147745