Human Brain scRNA-seq Data related to AD and cognitive decline

 

Human Brain scRNA-seq Data related to AD and cognitive decline 

1. Aging/AD Cortical Cell Atlas

   • Profiles 24 human frontal cortex samples with clinicopathologic traits (including cognitive decline metrics) using single-nucleus RNA-seq12.

   • Identified cell subtypes (e.g., SST+ inhibitory neurons, oligodendroglial states) and multicellular communities altered in Alzheimer’s disease (AD). Associations with tau pathology and cognitive decline were statistically validated12.

2. SCAD-Brain Database

   • Aggregates 17 AD/mild cognitive impairment (MCI) projects from public repositories (GEO, Synapse):

     • 21 datasets | 359 samples | 10 brain regions | 1.56 million cells36.

     • Supports analysis of cell communication, trajectory, and differential gene expression in AD/MCI vs. controls36.

   • Access: SCAD-Brain.