Estimating the genome-wide contribution of selection to temporal allele frequency change

 

https://www.pnas.org/content/117/34/20672

Estimating the genome-wide contribution of selection to temporal allele frequency change

Vince Buffalo and Graham Coop

PNAS August 25, 2020 117 (34) 20672-20680; first published August 12, 2020;

https://github.com/vsbuffalo/cvtk

use ODE model and noise to study epistasis using simulated yeast cell populations

No evidence that protein noise-induced epigenetic epistasis constrains gene expression evolution
Gábor Boross, Balázs Papp, 2016 MBE


Boros use analytic yeast glycolysis pathway model to study epigenetic interactions. Positive and negative epistasis were found by analyzing fitness of simulated large population of yeast cells with random levels of protein activities whose fitness is calculated with  a deterministic fitness function. 

Thalassemia

Thalassemia module References

https://en.wikipedia.org/wiki/Thalassemia

http://www.healthline.com/health/thalassemia#Symptoms3

http://www.ncbi.nlm.nih.gov/pubmed/22445352

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656091/pdf/ppat.1003327.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666573/pdf/ejhg2014131a.pdf

Tajima's D, D_non, D_syn

Tajima's D = D_non + D_syn
additive

seems to be used by Autin Hughs