Essential genes, gene networks in human, Jiang etal, Genome biology, 2015

Peng Jiang, X. Shirley Liu Genoem Biology, 2015, 16:239; network based prediction of essential genes

Essential genes in human are studied this paper. These data can be used for network aging modeling in human. 

3. 2014, Broad-DREAM Gene Essentiality Prediction Challenge. Available at: https://www.synapse.org/#!Synapse:syn2384331/wiki 

(Registration is needed for downloading the data)

"Recently published CRISPR loss-offunction screen data [4, 5, 8], and selected three cell

lines (K562, HL60, and A375) with publicly available gene expression data [26– 28]. "

4. Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelsen TS, et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science. 2014;343:84–7.

5. Wang T, Wei JJ, Sabatini DM, Lander ES. Genetic screens in human cells using the CRISPR-Cas9 system. Science. 2014;343:80–4.

8. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, et al. Genome-scale CRISPR-mediated control of gene repression and activation. Cell. 2014;159:647–61.

STRING network

The STRING network genes were grouped into 2,271 dense complexes using SPICi [31]. 

Roadmap project