lifespan - Why we age and why don't have to. David Sinclair
Sinclair claimed that he had the idea of the Information Theory of Aging on October 28, 1996, page 35, with a hand-written title provided therein.
Sinclair presented the arguments that DNA mutation is not a cause of aging, but the chaos air of epigenome such as DNA methylation is the major cause of aging.
Sinclair claims that "aging is a loss of information".
Hong think this is NOT right, at least based on Shannon's information formula, H = - sum( p* log(p)) , because in chaotic old aging, there would be more states and more randomness, so information entropy would increase not decrease. So, it seems that Shanon's H would increase during aging.
blogs on Sinclair's lifespan book:
https://hplus.club/blog/a-summary-of-david-sinclairs-information-theory-of-aging/
https://medium.com/intuitionmachine/deep-learning-and-solving-aging-21eaaa6eec8b#:~:text=David%20Sinclair's%20%E2%80%9Cinformation%20theory%20of,an%20organism%20eventually%20stops%20growing.
A good contradictory riddle in Sinclair's information theory of aging and reprogramming for youth:
https://hplus.club/blog/david-sinclairs-level-3-reversing-aging-with-the-yamanaka-factors/
No comments:
Post a Comment