Moreno 2019, elife, Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

 eLife. 2019; 8: e48240.Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

David F Moreno,1 Kirsten Jenkins,2,7 Sandrine Morlot,3,4 Gilles Charvin,3,4 Attila Csikasz-Nagy,2,7,5 and Martí Aldea1,6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744273/

Aging yeast cells mostly arrest in G1 phase with low nuclear levels of cyclin Cln3. Cln3 is a rate-limiting factor of START. 

SSA1, hsp70 family

Ydj1, hsp40 co-chaperone, DnaJ family