Elliott, McLaughlin, 1978 PNAS rate of macromolecular synthesis through cell cycle of the budding yeast

 

Elliott, McLaughlin, 1978 PNAS rate of macromolecular synthesis through cell cycle of the budding yeast

DNA synthesis is periodic. Rate of RNA and protein synthesis is an exponential increase.  

Based on bulk measurement by isotope labeling. 

The rate of RNA synthesis divided by total RNA is constant (Figure 3C), and the rate of protein synthesis divided by total protein is also constant (Figure 3A). So, the apparent rate of RNA/protein increase exponentially during cell cycle. 

         dM / M = C dt  which means d(log(M) = C dt, so, M = exp( C t).