RM11a and s288c differ 0.5-1%

 

https://www.broadinstitute.org/fungal-genome-initiative/saccharomyces-cerevisiae-rm11-1a-genome-project

"sequence divergence between RM11 and S288C is estimated to be 0.5-1%, approaching that between human and chimp. This sequence variation is distributed throughout the genome, confirming that RM11 shares no recent history with S288C."