W303 is a relative to S288c

 Open Biol. 2012 Aug; 2(8): 120093.

doi: 10.1098/rsob.120093

PMCID: PMC3438534

PMID: 22977733

The Saccharomyces cerevisiae W303-K6001 cross-platform genome sequence: insights into ancestry and physiology of a laboratory mutt

Markus Ralser,1,2,† Heiner Kuhl,2,† Meryem Ralser,2 Martin Werber,2 Hans Lehrach,2 Michael Breitenbach,3 and Bernd Timmermann2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438534/

The consensus W303-K6001 genome differs in 8133 positions from S288c, predicting altered amino acid sequence in 799 proteins, including factors of ageing and stress resistance. The W303-K6001 (85.4%) genome is virtually identical (less than equal to 0.5 variations per kb) to S288c, and thus originates in the same ancestor. 

Several of these clusters are shared with Σ1278B, another widely used S288c-related model, indicating that these strains share a second ancestor. Thus, the W303-K6001 genome pictures details of complex genetic relationships between the model strains that date back to the early days of experimental yeast genetics.

RM11-a

BY4742 alpha