R15 proposals in NIA

1R15AG053879-01
ROLE OF CIRCADIAN CLOCK COMPONENTS IN APOPTOSIS AND TAUOPATHY IN DROSOPHILA

https://projectreporter.nih.gov/project_info_details.cfm?aid=9171076&icde=39147502&ddparam=&ddvalue=&ddsub=&cr=27&csb=default&cs=ASC&pball=

CELL SIGNALING AND RESISTANCE TO OXIDATIVE STRESS: EFFECTS OF AGING AND EXERCISE.
https://projectreporter.nih.gov/project_info_description.cfm?aid=9225339&icde=39147502&ddparam=&ddvalue=&ddsub=&cr=8&csb=FY&cs=DESC&pball=

1R15AG050218-01A1
TESTING DIRECT EFFECTS OF REPRODUCTION ON LIFESPAN WITH CONTROLLED FEEDING IN GRASSHOPPERS
https://projectreporter.nih.gov/project_info_description.cfm?aid=9093113&icde=39147502&ddparam=&ddvalue=&ddsub=&cr=11&csb=FY&cs=DESC&pball=

1R15AG052933-01
THE ROLES OF SPHINGOLIPIDS IN STRESS RESPONSE AND HEALTHY AGING.
https://projectreporter.nih.gov/project_info_description.cfm?aid=9099409&icde=39147502&ddparam=&ddvalue=&ddsub=&cr=16&csb=FY&cs=DESC&pball=

1R15AG052149-01
REGULATION OF THE C. ELEGANS HEAT SHOCK RESPONSE BY LST-3
https://projectreporter.nih.gov/project_info_description.cfm?aid=9022936&icde=39147502&ddparam=&ddvalue=&ddsub=&cr=38&csb=default&cs=ASC&pball=

biogrid PPI

read my old codes:

applejack:qin.biogrid.code hqin$ pwd

/Users/hqin/data/biogrid/qin.biogrid.code

My code took 'physical' interactions from biogrid, and found only unique interactions.

standardize IC50 like pH?

https://www.collaborativedrug.com/buzz/2014/07/14/why-using-pic50-instead-of-ic50-will-change-your-life/

multiplicity of eigen value

The number of linearly independent eigenvectors associated with a given eigen value $lambda$ is called the geometric multiplicity of eigenvalue $lambda$.

matrix Jordan cannonical form and eigen values

http://mathworld.wolfram.com/JordanCanonicalForm.html

Eigen values in Jordan cannobucak form of matrix

estimate protein interactions based on network evolution

estimate protein interactions based on network evolution

https://www.sciencedirect.com/science/article/pii/S037843711730924X

qin 2003 pnas

*** naked mole rat, non-aging model?

elife:

Naked mole-rat mortality rates defy

Gompertzian laws by not increasing with

age

J Graham Ruby, Megan Smith, Rochelle Buffenstein*

Calico Life Sciences LLC, South San Francisco, United States

TODO: exponential signal + white noises :: exponential fitting
Gompertiz signal + white noises :: exponential fitting vs Gompertz fitting. Perhaps, there is just not enough statistical power?

Gym openAI

https://gym.openai.com/