membrane bending by proteins crowding

membrane bending by protein protein crowding,
https://www.nature.com/articles/ncb2561


disordered regions

Area_protein ~ R^2_G

random polymers: R_G ~ 5nm, Area_Epsin = 80 nm^2

Globular folded

Epsin, endocytic proteins are substantially disordered.

BAR domains,
 N-convex curvatures.
 I-BAR

Can IDP sense membrane curvature?

protein liquids. 3D protein fluid droplets. Eps 15, regulated by Fcho1, phase separation.