Monday, November 4, 2019

NIH data harmonization


Data Harmonization, Curation and Secondary Analysis of Existing Clinical Datasets (R61/R33 Clinical Trial Not Allowed)

https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-20-007.html

Examples of potential research topics include, but are not limited to:
  • Validation of diagnostic and/or prognostic models of outcome
  • Comparative effectiveness hypotheses
  • Mediation analyses of biological, cultural and environmental factors that affect treatment response or course of disease
  • Evaluation of biomarker validity (including clinical outcome assessments (COAs)), in new populations and/or new context of use
  • Discovery or validation of multi-domain clinical and/or biological measures for diagnosis, prognosis and/or treatment response using existing genetic and biological samples along with clinical and physiological assessments
  • Extended characterization or validation of natural history disease course
  • Novel methods for improving patient stratification
Examples of research that this RFA will not support include:
  • Studies using non-human animal models
  • Studies using data from a single clinical research study
  • Multiple single-site clinical research studies
  • Studies of harmonization, curation, and analysis where the primary data source is Electronic Health Record (EHR) data
  • Studies of harmonization, curation, and analysis where the primary data source is metadata

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