Data Harmonization, Curation and Secondary Analysis of Existing Clinical Datasets (R61/R33 Clinical Trial Not Allowed)
https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-20-007.html
Examples of potential research topics include, but are not limited to:
- Validation of diagnostic and/or prognostic models of outcome
- Comparative effectiveness hypotheses
- Mediation analyses of biological, cultural and environmental factors that affect treatment response or course of disease
- Evaluation of biomarker validity (including clinical outcome assessments (COAs)), in new populations and/or new context of use
- Discovery or validation of multi-domain clinical and/or biological measures for diagnosis, prognosis and/or treatment response using existing genetic and biological samples along with clinical and physiological assessments
- Extended characterization or validation of natural history disease course
- Novel methods for improving patient stratification
Examples of research that this RFA will not support include:
- Studies using non-human animal models
- Studies using data from a single clinical research study
- Multiple single-site clinical research studies
- Studies of harmonization, curation, and analysis where the primary data source is Electronic Health Record (EHR) data
- Studies of harmonization, curation, and analysis where the primary data source is metadata
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