Tuesday, February 16, 2021

trans effect on gene expression, heritability

 

https://www.cell.com/cell/fulltext/S0092-8674(19)30400-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419304003%3Fshowall%3Dtrue


GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

https://elifesciences.org/articles/58615

These GWAS show that GWAS hits are often found in pathway, though only count for ~10% heritability. 

This is related to Hong's network aging model on lifespan 


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