Someone mentioned that there is tradeoff between translation accuracy and speed. If translational accuracy leads to reliability change in general, it has global effect on function decay rate in my network aging model. This may be used to model the ribosomal effect on lifespan.
This argument would suggests that codon bias is related to network reliability and aging. So, codon bias modification may influence aging dynamics? Can better codon bias lead to long lifespan, smaller m0 and large G (more homogeneity)?
The mRNA ribosomal profiling is a measure of translation activity.
In E coli, slow translation is found when ribosomal proofreading is more active.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC557732/
http://www.sciencedirect.com/science/article/pii/S0968000400017370
Wuttle12 proposed a meiosis-related rejuvenation process for CR.
slow growth and high protein fidelity?
rpl20b: null leads to slow vegetative growth
ndt80
tor1
sch9
July 15, 2015:
transcriptional fidelity?
http://www.ncbi.nlm.nih.gov/pubmed/26159996
August 13, 2015 rogue ribosome translation
http://phys.org/news/2015-08-biologists-ribosomes-untranslated-region-messenger.html
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