Tuesday, December 8, 2015

yeast mutations, zhu, petrov pnas2014

Zhu14 sequenced 145 diploid sce strains undergone mutation accumulations.
Zhu14 concluded "neighbor-dependent mutation rate". These neighbor refer to adjacent nucleotides.
Zhu14 did not found significant correlation between GC content, replication timing, transcription levels to mutation frequencies.

Data of mutations are provided in coordinates


Data at:
http://www.pnas.org/content/suppl/2014/05/20/1323011111.DCSupplemental/pnas.1323011111.sd01.txt

Todo: distribution of the mutation in network? correlation with dn, ds?

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