cancer network analysis, 2014 Leiserson et al, Nature genetics

2014 Nature genetics

 Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

Mark D M Leiserson1,2,14, Fabio Vandin1,2,13,14, Hsin-Ta Wu1,2, Jason R Dobson1–3, Jonathan V Eldridge1, Jacob L Thomas1, Alexandra Papoutsaki1, Younhun Kim1, Beifang Niu4, Michael McLellan4, Michael S Lawrence5, Abel Gonzalez-Perez6, David Tamborero6, Yuwei Cheng7, Gregory A Ryslik8, Nuria Lopez-Bigas6,9, Gad Getz5,10, Li Ding4,11,12 & Benjamin J Raphael1,2

"URLs. HI2012 interactome, http://interactome.dfci.harvard.edu/; HotNet2 pan-cancer analysis website, http://compbio.cs.brown.edu/pancancer/hotnet2/; RNA expression data used for the TCGA pan-cancer data set, https://www.synapse.org/#!Synapse:syn1734155; pan-cancer mutations with additional germline variant filtering, https://www.synapse.org/#!Synapse:syn1729383; HotNet2 software release, http://compbio.cs.brown.edu/software."