Wednesday, October 25, 2017

tissue specific gene regulation

How does these affect aging, controllability? Some tissue aging fast and some slow?


  • Regulatory network connections are more tissue specific than nodes (genes and transcription factors)
  • Tissue-specific function is not solely regulated by transcription factor expression
  • Tissue-specific genes assume bottleneck positions in their corresponding networks
  • Tissue specificity is driven by context-dependent, non-canonical regulatory paths

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