tissue specific gene regulation

How does these affect aging, controllability? Some tissue aging fast and some slow?

http://www.cell.com/cell-reports/abstract/S2211-1247%2817%2931418-3#.We-APbV2phM.facebook

Highlights

• •Regulatory network connections are more tissue specific than nodes (genes and transcription factors)
• •Tissue-specific function is not solely regulated by transcription factor expression
• •Tissue-specific genes assume bottleneck positions in their corresponding networks
• •Tissue specificity is driven by context-dependent, non-canonical regulatory paths