Saturday, October 13, 2018

genome wide crisp screen in human pancreatic tumor cell line

* Nature medicine, 2017. genome wide SCRIPS screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43 mutant pancreativ tumaors
raw reads counts in Excel table

From the paper, Bayes Factor BF is the confidence of a gene caucses a decrease in fitness. So, high BF indicates decrease in fitness (essential genes), and low BF indicate proliferation.

FZD5 genes shows highest BF factor in 3 pancreatic cancer cell lines, but not in other cells lines. Hence, its essentiality is "context sensitive".

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