~3/4 of mother cells had at least 1 genome-level mis-segregation (GLM) during their replicative lifespan. In 90% of the GLMs, mother cells can correct them (some genetic materials seem to be transferred from daughter cells to mother cells, according to Hong's reading of this paper). This suggests that mitotic mechanic errors occur at a rate of ~3%.
100 cells, 25 RLS, so, 75 / 100*25 events = 3%.
The fatal error rate is 3% * (1- 90%) = 0.3%.
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