Hou et al 2012, systems biology of aging, Current Genomics, vol 13, No 7, p 561
Hou12 reviewed network-based approach to infer change during aging. Hou12 observed that subnework modules with correlated transcriptional changes during aging. One concern that I have is that microarray are measured for survived cells, and those dead cells cannot be measured. So, the observed changes are not "causes" of aging, but consequences of selection during aging.
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