Notes on Dhahbi 02 PNAS Calorie restriction in mice

Dhahbi et al, 2002, PNAS, temporal linkage between the phenotypic and genomic responses to caloric restriction.

Fig 1. Survival curve between control and CR groups seem to suggest that CR has a sharper transition (large Gompertz coefficient), and smaller initial mortality rate, too. This seems to suggest a mix-population.

Dhahbi02 found at CR has an immediate effect on mortality rate, carcinogenesis, and genomic responses.