Alex Lang, Boston University (4th graduate student)
Epigenetic landscapes provide insight into cellular programming,
Takahashi, Yamanaka 2006, converted epithelia to stem cells. Terminal cells can be converted to another terminal cell types without going through the 'stem' cell stages.
Waddington landscape 1957, thinks cell types as dynamic attractors.
Lang argued that Waddinton landscape is a emergent property of underling interaction networks.
Lang: Cell type = high dimenstional Ising spin vector.
Landscape construction:
Each cell is a vector. Each cell is a basin of attraction.
Project method neural network is a method to take vector and construct landscape.
( Hopfiled PNAS 1982? )
Attractors due to correlation-based effective interaction matrix.
High demensions often give spurious attractors, an unavoidable for frustrated systems.
Lang claimed that partially reprogrammed cells are the spurious attractors.
Lang developed a project method to match vectors to cell types.
Reprogramming facts: only final cell types matters, only one set of TFs in time.
Lang claimed that partially reprogrammed cells are the spurious attractors.
Lang developed a project method to match vectors to cell types.
Reprogramming facts: only final cell types matters, only one set of TFs in time.
URL:
http://q-bio.org/w/images/8/89/Talk_LangAlex.pdf
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