Heterogeneous Differentiation Patterns of Individual CD8+ T Cells,
Rob De Boer, Utrecht University
http://theory.bio.uu.nl/rdb/
http://theory.bio.uu.nl/rdb/publications.html
Bar coding of cells using retroviral library. Deep sequencing to find distribution of cells.
50% of total immune responses derived from 5% of the cells
50% of the families contain less than 200 daughter cells.
Disparity in family sizes is established early.
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