Tuesday, July 4, 2017

Cancer research grand challenge

Upper  £20,000,000GBP
Each shortlisted team will be awarded up to £30,000 seed funding.

Winning teams will receive an award of up to £20 million, typically over five years.
Applicant Type
Individuals: Early Career and Emerging in Field
Individuals: Mid-Career to Established in Field
Citizenship or Residency
Activity location
Grand Challenge awards are the most ambitious cancer research grants in the world. They're intended to catalyse a revolution in how we prevent, diagnose, and treat cancer by bringing together the brightest minds around the globe, providing the freedom to undertake innovative, game-changing research.

CRUK are looking for applications from interdisciplinary teams with novel, exciting ways of solving one of seven Grand Challenges, which together encompass some of the most important unanswered questions in cancer research. If applicants can convince CRUK they're on to something extraordinary, CRUK will give the team up to £20m to prove it. Cancer Research UK is seeking scientific adventurers who are willing to take risks in exchange for the ultimate reward - making cancer a disease that no longer inspires fear.

An independent advisory panel have now set 8 new Grand Challenges and are inviting the world's top scientists to come together proposing novel ways to tackle them.

- Tissue Specificity
Devise approaches to prevent or treat cancer based on mechanisms that determine tissue specificity of some cancer genes.

- Tumour Vaccinology
Create novel tumour vaccinology approaches that establish or enhance successful immune responses beyond what is revealed by current checkpoint therapy.

- Treatment Regimens
Define mechanistic rules for combinatorial treatments to overcome resistance and avoid toxicity.

- Dormancy
Identify and target tumour cells that remain dormant for many years after seemingly effective treatment.

- Lethal vs non-lethal
Distinguish between lethal cancers which need treating, and non-lethal cancers that don't.

- Artificial Intelligence
Detect cancer earlier by interrogating medical and non-medical data sets using machine and deep-learning.

- Microbiota
Improve treatment responses by manipulating the composition and status of the microbiota.

- Cancer Causes
Determine the mechanisms that cause cancer without known mutagenesis, such as obesity, in order to devise novel interventions. 
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CRUK will support the best scientists from around the world and enable the optimal mix of disciplines and approaches. Teams are expected to be international in nature, with roughly 25% of the team being based in a different country from the rest of the consortium. There is no requirement for any of the team members to be based in the UK.

Academic-commercial collaboration is encouraged within individual Co-Investigator-led work packages.

Applicants are encouraged to consider the balance of gender and career-stage within their teams.

Teams are encouraged to look for opportunities to build patient involvement into their research. At a minimum, each team is expected to have a patient representative with a clearly defined role and remit. 
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