The companion dog as model for human morbidity and mortality.- Sex specific regulation of aging in Caenorhabditis elegans.
Headline vs Study
- Headline: Easing the brakes on the “immortality” enzyme could slow aging.
- Study: A single nucleotide incorporation step limits human telomerase repeat addition activity.
- Headline: “Axis of aging” mechanism uncovered in worms.
- Study: Brain-gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans.
Contrary or Null Findings
- Genetic ablation of p16 does not protect against cellular senescence in a mouse model of COPD.
- Higher peripheral IGF-1 better for aging brain in women.
- Carnitine supplementation does not improve muscle strength nor blood parameters in older women.
Energetics/Nutrition
- 40% dietary restriction improves glucose tolerance for a least 2 months after being returned to ad libitum diet.
- Calorie restriction reduces mTOR signaling in gut stem cells causing improved intestinal epithelium regenerative capacity.
- Water based aquatic exercise improves functional capacity and quality of life in elderly women.
Basic Biology
- Does a declining immune system cause the age-related increases in cancer incidence?
- Geropathology grading platform: a new way to assess aging rate.
- Yeast replicative lifespan limited by increased ribosomal DNA instability and reduced double stranded break repair.
- Metformin supplementation changes adipose and muscle transcriptomic profiles in older adults.
- Insulin signaling regulates oocyte quality maintenance with age via cathepsin B activity.
- Satellite cell mutations drive age-related skeletal muscle function.
- Circadian rhythms in cytosine modifications involved in epigenetic diversity and aging.
- Specific alleles of FOXO3 are associated with self-rated health in older adults.
- A novel mouse model of Alzheimer’s disease has alleviated symptoms with NAD+ supplementation.
- Review: The genetics of longevity in humans and mice.
- Review: Protein turnover in aging and longevity.
- y Only 15% of lifespan extending genetic interventions in mice actually slow the rate of aging.
- In mice, older fathers, faster aging.
Ecology & Evolution
- Stronger social bonds do not always predict greater longevity in a gregarious primate.
- Life history traits of a long-lived Australian fish, the leatherjacket.
- Environmental conditions and body mass senescence in the yellow-bellied marmot.
- Life-history traits of the alpine fly Drosophila nigrosparsa.
- Women who have reproduced have shorter telomeres than nulliparous women.
Novel Organisms/Comparative
- Aging and longevity in the flatworm Macrostomum lignano.
- Cellular senescence in naked mole rats.
- Telomere lengths in long-lived bats.
- The green vervet as model for neurodegenerative disease.
- Increased depth, increased longevity: Sessile marine taxa are longer lived at lower ocean depths.
- Review: FOXO3 and exceptional longevity: Insights from hydra to humans.
Epidemiology/Demography
- Cardiometabolic health is worse in older blacks compared to whites and Hispanics.
- Jail inmates develop geriatric conditions at younger ages than non-incarcerated adults.
- Heavy alcohol use is associated with increased risk of early onset dementia. (pdf)
- Socioeconomic depravation is associated with decreased survival in older adults.
Policy/Ethics
Clinical
- The power of a positive attitude? Older adults with the APOE4 allele are 50% less likely to develop dementia if they view aging positively.
- Obese older adults are more likely to fall, but less likely to be injured by a fall, than normal weight individuals.
Odds & Ends
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