Friday, May 7, 2021

GTEx protected data

 the GTEx portal,  "who can apply":

Extramural Investigators must be permanent employees of their institution at a level equivalent to a tenure-track professor or senior scientist with responsibilities that most likely include laboratory administration and oversight. Laboratory staff and trainees such as graduate students and postdoctoral fellows are not permitted to submit project requests.

Here is a link that walks through the application process: 

Here is the "request access" page on the first step:

From there, you can click on the "How does one apply" link and it will walk though all the steps.

Tips: 
https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/GetPdf.cgi?document_name=GeneralAAInstructions.pdf
dbGAP project PI: 

Research Use Statement. The approval of project requests depends primarily on a carefully written Research Use Statement (2,200 characters max). The statement should include the following components: • Objectives of the proposed research; • Study design; • Analysis plan, including the phenotypic characteristics that will be evaluated in association with genetic variants; • Explanation of how the proposed research is consistent with the data use limitations for the requested dataset(s); and • Brief description of any planned collaboration with researchers at other institutions, including the name of the collaborator(s) and their institution(s).


From T Day: 
I’ve been doing some digging to try and find the GTEx policy on data limitation. I found this document (attached) which highlights that they follow the NIH Genome Data Sharing GDS policy (found here: 
https://osp.od.nih.gov/scientific-sharing/genomic-data-sharing/ ) with slight variations. These variations are noted in the attached document which I was able to locate in the documentations section of the GTEx portal. 


GTEx Data Release and Publication Policy version 5-8-15
https://storage.googleapis.com/gtex-public-data/GTEx_Data_Release_and_Publication_Policy_v05-08-15.docx 

It is the intent of the NIH to promote the dissemination of research findings from NIH genomic dataset(s) as widely as possible through scientific publication or other appropriate public dissemination mechanisms. The Genotype-Tissue Expression (GTEx) project will follow the 8-27-14 Genomic Data Sharing (GDS) policy (gds.nih.gov/index.html) with the following exceptions:

1. Pilot data set (phs000424.v3.p1) - acceptance of the “Ft. Lauderdale” principles of rapid, pre-publication data release (see Sharing Data from Large-Scale Biological Research Projects: A System of Tripartite Responsibility, 2003). The continued success of rapid pre-publication data release relies on the scientific community to respect the data producer’s interest to publish a full analysis of their data first. Secondary users are asked to refrain from submitting manuscripts describing comprehensive analyses until the Consortium has published their analysis. 
May 8, 2015 - No restrictions - main manuscript published.

2. phs000424.v4.p1 - the dataset is subject to 9 months publication restriction starting from the date of the release; no restrictions after Jan 4, 2015. 

All datasets from phs00424.v5.p1 forward will follow the NIH GDS policy.  This means that once released through dbGaP, there are no restrictions on use or publication.  This document and an accompanying table of dataset releases can be found at http://www.gtexportal.org/home/documentationPage.

Overall, users of GTEx data are strongly encouraged to publish their results in peer-reviewed journals and to present research findings at scientific meetings, etc. Investigators planning to conduct analyses similar to those described at http://www.gtexportal.org/home/documentationPage may contact Consortium members or the NIH program staff at nhgrigtex@mail.nih.gov to discuss collaborations, if so desired






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