heterogeniety in yeast colonies,

=> Palková groups argues that yeast colony is a model of multi-cellular organism.

http://onlinelibrary.wiley.com/doi/10.1111/1567-1364.12103/abstract

=> prion like proteins in responses to enviromental cues such as bacteria

=> TF stochastically binds to DNA

=> limited macro-molecules, crowded space within cells