Finseth
CenH3
female gametogensis is asymmetric, only one egg but 3 poly bodies. So, there is advantage for genes to be meiotic drivers.
Malik & Hensoff 2001, centromeric drive model. Cost associated with meiotic drive.
Mimulus best case of centromere meiotic drive. Fishman et al 2005, 2008.
strong hetero-specific drive. M nasutus vs M. guttatus
weak conspecific drive in M. guttatus
Do CenH3 and centromer co-evolve?
Most abundant repeats in WG tend to be centromeric repeats
Finseth found many codons with >2 omega.
Finseth look for GWS in F2 plants, 122 individuals, 1247 markers (14 linkage groups, 14 chromosomes)
Look for genetic suppresor of CenH3 meiotic drive using genewise linkage disequilibrum (r^2),
D in nonrecombining block, suggesting recent selective sweep (Q: how is genetic surfing excluded? )
CenH3A and CenH3B
plan for population
Mimulus does not grow in TN?
Silene in TN
dioecious species
gynodiecious species
hermaphrodites
Reference
https://en.wikipedia.org/wiki/Mimulus
https://www.nature.com/articles/s41598-017-17932-8
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