Guo: I think this is explained in the paper, van Leeuwen et al., "Exploring genetic suppression interactions on a global scale", Science (2016), 354:aag0839.
This paper mentioned synthetic letality but did not explicitly define if it is a positive or negative interaction. However, I think genetic interactions derived by synthetic lethality should be negative effect. As the positive effect indicates that if mutation of gene A causes a reduced fitness, the double mutation of A and B restored the fitness, and hence gene B is a genetic suppressor of gene A.
I cannot find it on the CellMap website. However, from the NxN database and the fitness data I identified 2191 negative GI's , in which the double mutant fitness (DMF) is lower than 0.1. You may use different criterion, e.g., 159 interactions with DMF <= 0; or 193 with DMF <= 0.01, etc.
See the attached csv file (ranked by the DMF).
According to DCell paper, Ma et al, synthetic leathal is an example of negative genetic interaction. see its Figure 3, negative interaction between pmt1D and ire1D.
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