To combine 6
phenotypic measures for each SNP, one way is the Fisher’s method. When null
hypotheses are true for all association tests, they are independent by
definition, and their p-value can be combined as
for K
number of traits. To correct for multiple tests, phenotypic data will be
permuted 1000 times, and lowest p-value from each test will be used to generate
a distribution to determine proper genome-wide significance.
It seems reasonable to extrapolate this to combine q-values for multiple tests.
It seems reasonable to extrapolate this to combine q-values for multiple tests.
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