Monday, July 7, 2014

Zhao et al Cell, 2005, navigating chaperone network, hsp90

Hsp90 regulates 10% of the yeast genome, 627 putative hsp90 substrates.

Zhao05Cell used geldanamycin screen 4 times, and found 200 ORFs dependent on Hsp90 for, provided in table S4.

Notable missing 'known(?)' substrates: Ste11, Hap1, Ctf13/Skp1, Rpn components of proteasome.

49 ORF genetically interacts with Hsp90 by SGA and GS.

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