20140707
two-fold increase of protein level OSH6
increase # of interactions (new interactions)
stronger interaction (low p to high p)
artificial interactions vs endogenous interactions
some Y2H may be artificial.
TCO89 knock-down lead to shorter lifespan.
"interaction intensity", Tco89 - Tor1, p=0.5 in mutant, p=1 in wildtype. "Competition can be modeled" in interaction intensity modeling. Conservation of mass for Tor1.
CR lead to decreased endocytosis in yeast, claimed by Tang. Vacole is the end organelle to digest food imported by endocytosis.
How about autophagy?
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