Thursday, August 6, 2015

qbio day2

microfuidic chip: pulse and change mediam of cells. useful for my radicicol experiment.

geodesic curves

=> microbes under pressure, oskar hallatscheck, uc berkley

hypothesis: crowded microbes change their behaviors

Single cell assay for fission yeast. Minc et al Current biology,

Trapped fission/budding yeast cells in microfluidic devices.

natural isolates (haploids) are valtro like and can generate much larger tugor pressure and crack PDMS device and agar plate.
Q: invasive pathogenic and noninvasive strains?

=> IgE, cornell, molecular memory
microfludic chamber for mast cells
pulse of signals


"Our findings strongly suggest that the low channel capacities previously observed at a single cell level does not reflect an inherent physical limit, but rather a natural trade off between information transfer at the single cell vs. population levels. This implies that the level of noise in individual signaling networks and cells can be regulated to produce reliable information at the level of individuals or populations, depending on the phenotypic requirements of the organism."

=>14:30-15:00 Alejandro Colman-LernerUniversity of Buenos AiresUse of information far from steady-state by signal transduction systems.
budding yeast pheromone mating pathway.

yeast with truncated Ste2, fluorescent alpha factor, --> dose reponse of ligand binding to receptor.


On the connection between computational and biochemical measurement

=> 15:20-15:40 Jeremy PurvisUNC-Chapel HillSingle-cell dynamics reflect underlying signaling mechanisms

single cell data shared by Nan Hao, Andrew Hans and Erin O'Shea

=> Arthur Lander's group, Abed AlnaifUC IrvinePattern formation and morphogen gradients: A causality dilemma

=>16:30-16:50 Vernita GordonUT-AustinThe bacterial population’s spatial structure non-monotonically impacts bacterial growth
planktonic and biofilm bateria

=>16:50-17:10 Nicholas C. ButzinVirginia TechEntrainment of synthetic gene oscillators by a noisy stimulus

=> Jeff Gore, mit
ecological systems biology, cross-protection allows a mixed population to survive,

flow cytometer monitoring of two population, two kinds of antibiotics

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