Sunday, January 1, 2017

control coefficient and metabolic control

control coefficient, which is similar to sensitivity analysis and defines relative changes of a system (e.g. fluxes or concentrations) in response to a perturbation.
See Kacser & Burns 1973, 
Heinrich & Rapoport 1974, 
Burns et al. 1985
Kacser, H. & Burns, J.A. (1973) The control of flux. Symp. Soc. Exp. Biol. 27, 65-104.
Heinrich, R. & Rapoport, T.A. (1974) A linear steady-state treatment of enzymatic chains. General properties, control and effector strength., Eur. J. Biochem. 42, 89-95.
Burns, J.A., Cornish-Bowden, A., Groen, A.K., Heinrich, R., Kacser, H., Porteous, J.W., Rapoport, S.M., Rapoport T.A., Stucki, J.W., Tager, J.M., Wanders, R.J.A. & Westerhoff, H.V. (1985), Control of metabolic systems. Trends Biochem. Sci. 10, 16.

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