use ODE model and noise to study epistasis using simulated yeast cell populations

No evidence that protein noise-induced epigenetic epistasis constrains gene expression evolution
Gábor Boross, Balázs Papp, 2016 MBE


Boros use analytic yeast glycolysis pathway model to study epigenetic interactions. Positive and negative epistasis were found by analyzing fitness of simulated large population of yeast cells with random levels of protein activities whose fitness is calculated with  a deterministic fitness function.