Finding the sources of missing heritability in a yeast cross
Joshua S. Bloom1,2, Ian M. Ehrenreich1,3, Wesley T. Loo1,2, Thu´y-Lan Vo˜ Lite1,2 & Leonid Kruglyak1,4,5
Nature, 2013
Nature, 2013
Bloom13 measured 1008 haploid segregants from a BYxRM cross. All strains are genotyped by deep sequencing. 30.6K SNPs were identified, which is about 0.5%.
Bloom13 stated that difference between broad sense heritability H^2 and narrow sense heritability h^2 is due to gene-gene interaction. Bloom13 showed that most additive heritability are explained by detected QTL. (This is somewhat expected, isn't it? This is what linear regression is designed for.).
Bloom13 provided their raw data and code. This is a great effort.
There are several reviews and comments on this publication. One comment is on the 50% allele frequency in this controlled study. Both Brookfield13 and Bloom13 seem to define missing heritability
http://genomics-pubs.princeton.edu/YeastCross_BYxRM/
Brookfield, 2013, Current biology, Quantitative Genetics: Heritability Is Not Always Missing
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