This site is to serve as my note-book and to effectively communicate with my students and collaborators. Every now and then, a blog may be of interest to other researchers or teachers. Views in this blog are my own. All rights of research results and findings on this blog are reserved. See also http://youtube.com/c/hongqin @hongqin
Friday, June 21, 2013
Limiting gene interaction and network aging
To evaluate a mutant effect, the null hypothesis is that the effect is the same with the control. In this case, I can partition the wildtype survival function into the bulk and limiting module with a mixing parameter. Both wildtype and mutant lifespan data can be fitting with the null model.
Alternatively, mutant survival functions can be fitting with different parameters.
Likelihood ratio test, AIC or BIC can be used. Alternatively, permutation of experimental data can be used to generate the null-distribution.
Labels:
limiting module,
network aging,
qin
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