Microsatellites are short tandem DNA repeats tend to have high mutation rates due to DNA replication slippage.
An analogy to help students understand this phenomena is to ask them to count beads on beaded bracelets. If all the beads are the same (tandem repeats), we can easily slipped one or two beads. If beads are colored, our counting can be more accurately tracked. This analogy worked in Bio125, Spring of 2013.
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