Xue07 examined PPI in fruit fly and human brain aging. Xue07 used simulation and stated that "aging might preferentially attack key regulatory nodes that are important for the network stability, implicating a potential molecular basis for the stochastic nature of aging".
Xue07 identified negative (N) and positive (P) correlations during aging based on expression data, and then identified the PPI subnetwork for these NP correlations. Xue07 then used clustering method to identify 'network modules'.
Its method paper is in
Xia K, Dong D, Xue H, Zhu S,Wang J, Zhang Q, Hou L, Chen H, Tao R, Huang Z, Fu Z, Chen YG, Han JD (2006) Identification of the proliferation/differentiation switch in the cellular network of
multicellular organisms. PLoS Comput Biol 2: e145
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