In K05, genes were separated into LL, NLL, and SL. LL null mutants extend RLS >=30%. Putatively, LL RLS <= 20, and LL RLS >=36. Experiments were repeated until classification can be established. In K05, LL strains can extend RLS with Wilcoxon rank-sum test p-value <0.1, and NSE mutants are those with RLS longer than WT but with p-value >0.1
Byte:Kaeberlein05Science hqin$ cat confirmed.LL.txt
YNR051C BRE5
YDR110W FOB1
YOR136W IDH2
YBR267W REI1
YLR371W ROM2
YDL075W RPL31A
YLR448W RPL6B
YJR066W TOR1
YNL229C URE2
YBR238C
YBR255W
YBR266C
There are 13 LL genes in this list, too few for svm training. It seems that I expanded this list using the ratio of mutant/wt RLS. K05 initially identified 44 putative LL, but only 13 were significant.
Q: How are these categories hold in He14 classification? Why did He14 did not use Kaeberlein05 data?
I need to compare Kaberlein05 with He14 classifications.
Q: How are these categories hold in He14 classification? Why did He14 did not use Kaeberlein05 data?
I need to compare Kaberlein05 with He14 classifications.
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