I study computational and quantitative biology with a focus on network aging. This site is to serve as my note-book and to effectively communicate with my students and collaborators. Every now and then, a blog may be of interests to other researchers or teachers. Views in this blog are my own. All rights of research results and findings on this blog are reserved. See also http://youtube.com/c/hongqin
Sunday, January 11, 2015
564 RLS data from Kaeberlein 05 Science
The 2005 564 RLS data were provided both in Kaeberlein05Science and Managbanag08PlosOne.
In K05, genes were separated into LL, NLL, and SL. LL null mutants extend RLS >=30%. Putatively, LL RLS <= 20, and LL RLS >=36. Experiments were repeated until classification can be established. In K05, LL strains can extend RLS with Wilcoxon rank-sum test p-value <0.1, and NSE mutants are those with RLS longer than WT but with p-value >0.1
There are 13 LL genes in this list, too few for svm training. It seems that I expanded this list using the ratio of mutant/wt RLS. K05 initially identified 44 putative LL, but only 13 were significant.
Q: How are these categories hold in He14 classification? Why did He14 did not use Kaeberlein05 data?
I need to compare Kaberlein05 with He14 classifications.