MSH2 PDB and complex with DNA mismatch repair

human MSH2 protein domain

http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=53935

Interpro Scan results

Structure of the human mutsalpha DNA lesion recognition complex.

Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS

Mol.Cell (2007) 26 p.579

alignment of yeast MSH2 to Ecoli MutS, PDB complex with DNA mismatch
http://www.yeastgenome.org/cgi-bin/protein/get3d?locus=YOL090W&pdb=1E3M_A&align=1

MSH2 PDB and complex with DNA mismatch repair
http://www.rcsb.org/pdb/results/results.do?outformat=&qrid=2EB9A71A&tabtoshow=Current

MSH2,MSH6 complex with DNA
http://www.ncbi.nlm.nih.gov/structure?Db=structure&DbFrom=protein&Cmd=Link&LinkName=protein_structure&LinkReadableName=Structure&IdsFromResult=4557761


2O8B. ADP seems to be bound to chain B(MSH6)? NCBI site seems to suggest that ADP (chain2) interacts with both chain A and chain B.

The mismatch is between G-T, in which G is modified probably to stabilize the mismatch.

8th residue in chain E is 6oG, which is the center of the 15-mer.
8th residue in chain F is T.  So, the mismatch is G-T.

I tried to use SPBDV to find the protein residues in proximity of the mismatched GT, but it was not a easy task.