(BUILD) human gene network reliability and pathogenic association of genetic variations in human populations

Reliability of human gene networks and their pathogenic implications.

Reliability of gene network in different human tissues and cell types -> robustness, cancer incidence?

health disparity
aging associated genes

expression profiling, ngs to infer tissue specific gene networks.

human twin aging expression
http://genomebiology.com/2013/14/7/R75?utm_campaign=10_12_13_genomebiol_Article_Mailing_Reg&utm_content=7387379393&utm_medium=BMCemail&utm_source=Emailvision

gwa aging 

http://www.ncbi.nlm.nih.gov/pubmed/21782286

age of puberty in japanese

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063821

CR effect on cell lines SNPS
flow cytometers
fluorecesnce microscope

yeast model?